GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2858829 | 1 | rs2637678 | chr6:116787378 | FAM26F | chr6:116782556-116784933:+ | 0.47 | 4.89 | 4.17E-6 | Ulcerative colitis |
| THYM | cis | rs1499614 | 1 | rs2659903 | chr7:66180931 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs1499614 | 1 | rs2659911 | chr7:66158420 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs1499614 | 1 | rs2659913 | chr7:66157336 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs9815354 | 1 | rs2683695 | chr3:41914928 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs2683696 | chr3:41914898 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs1499614 | 1 | rs2707828 | chr7:66171377 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs1499614 | 1 | rs2707830 | chr7:66167645 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs2243480 | 1 | rs2707831 | chr7:66062511 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Diabetic kidney disease |
| THYM | cis | rs1499614 | 1 | rs2707832 | chr7:66136549 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs1499614 | 1 | rs2707838 | chr7:66159201 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs1499614 | 1 | rs2707840 | chr7:66158015 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Gout |
| THYM | cis | rs2243480 | 1 | rs2707844 | chr7:66059509 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Diabetic kidney disease |
| THYM | cis | rs2294008 | 1 | rs2717562 | chr8:143776668 | PSCA | chr8:143761875-143764142:+ | 0.42 | 4.21 | 5.89E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2734839 | 1 | rs2734839 | chr11:113286490 | TTC12 | chr11:113185251-113244016:+ | -0.31 | -4.37 | 3.15E-5 | Information processing speed |